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Research

Our lab is dedicated to interdisciplinary research. Focused on both basic translational research and clinical research, our mission is to create translational pipelines, from animal to human, in order to improve the diagnosis, prevention, and treatment of mental disorders and addiction.


Translational research

In our basic translational research projects, we address problems with learning and memory, emotion, motivation, and attention. We combine various methodologies including behavioral, genetic, pharmacological, and neurochemical approaches to assess the respective processes across different species (i.e., rats, mice, and humans). The overall aim of this work is to translate the findings into potential clinical applications.


Binder, S., Dere, E., Zlomuzica, A. (2015). A critical appraisal of the what-where-when episodic-like memory test in rodents: Achievements, caveats and future directions. Progress in Neurobiology, 130, 71-85.

Zlomuzica, A., De Souza Silva, M.A., Huston, J.P., Dere, E. (2007). NMDA-receptor modulation by D-cycloserine promotes episodic-like memory in mice. Psychopharmacology, 193, 503-509.

Zlomuzica, A., Tress, O., Binder, S., Willecke, K., Dere, E. (2012). Changes in object recognition and anxiety-like behaviour in mice expressing a Cx47 mutation that causes Pelizaeus-Merzbacher-like Disease. Developmental Neuroscience, 34, 277-287.

Tress, O., Maglione, M., May, D., Pivneva, T., Seyfarth, J., Binder, S., Zlomuzica, A., Theis, M., Dere, E., Kettenmann, H., Willecke, K. (2012). Panglial gap junctional communication is essential for maintenance of myelin in the central nervous system. Journal of Neuroscience, 32, 7499-7518.

Dere, E., Zlomuzica, A. (2012). The role of gap junctions in the brain in health and disease. Neuroscience & Biobehavioral Reviews, 36, 206-217.

Tress, O., Maglione, M., Zlomuzica, A., May, D., Dicke, N., Degen, J., Dere, E., Kettenmann, H., Hartmann, D., Willecke, K. (2011). Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation associated with Pelizaeus-Merzbacher-like disease in humans. PLOS Genetics, 7:7: e1002146.


Clinical research

Our clinical research aims to understand the pathophysiological mechanisms that are responsible for the development, progression and chronification of mental disorders, such as addiction, affective and anxiety disorders. Findings from our basic and clinical research is used to optimize and refine conventional treatment approaches, as well as to develop novel, e.g., learning and memory based, treatment programs to reduce the patients suffering, symptom intensity and also to prevent relapses.


Zlomuzica, A., Dere, D., Machulska, A., Adolph, D., Dere, E., Margraf, J. (2014). Episodic memories in anxiety disorders: Clinical implications. Frontiers in Behavioral Neurosciences, 8, 131.

Zlomuzica, A., Woud, M. L., Machulska, A., Dietrich, L., Kleimt, K., Assion, H. J., Wolf, O. T., Dere, E., Margraf, J. (2017). Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder. Progress in Neuropsychopharmacology & Biological Psychiatry.

Zlomuzica, A., Preusser, F., Totzeck, C., Dere, E., Margraf, J. (2016). The Impact of Different Emotional States on the Memory for What, Where and When Features of Specific Events. Behavioural Brain Research, 298, 181-187.

Zlomuzica, A., Machulska, A., Roberts, S., von Glischinski, M., Rinck, M., Lester, K. J., Eley, T.C., Margraf, J. (2017). The dopamine D2 receptor mediates approach-avoidance tendencies in smokers. European Archives of Psychiatry and Clinical Neuroscience, 1-8.

Machulska, A., Zlomuzica, A., Rinck, M., Assion, H. J., Margraf, J. (2016). Approach bias modification in inpatient psychiatric smokers. Journal of Psychiatric Research, 76, 44-51.

Machulska, A.,* Zlomuzica, A.,* Adolph, D., Rinck, M., Margraf, J. (2014). “A cigarette a day keeps the goodies away”: Smokers show automatic approach tendencies for smoking - but not for food-related stimuli. PloS One, 10, 2: e0116464